Journal article
Immunosuppressive Properties of Mesenchymal Stem Cells
M Abumaree, M Al Jumah, RA Pace, B Kalionis
Stem Cell Reviews and Reports | Published : 2012
Abstract
Mesenchymal stem cells (MSC) can be isolated from different adult tissues including bone marrow, adipose tissue, cord blood and placenta. MSCs modulate the immune function of the major immune cell populations involved in alloantigen recognition and elimination, including antigen presenting cells, T cells, B cells and natural killer cells. Many clinical trials are currently underway that employ MSCs to treat human immunological diseases. However, the molecular mechanism that mediates the immunosuppressive effect of MSCs is still unclear and the safety of using MSC in patient needs further confirmation. Here, we review the cytokines that activate MSCs and the soluble factors produced by MSCs, ..
View full abstractRelated Projects (1)
Grants
Awarded by Cecilia Kilkeary Foundation
Funding Acknowledgements
We wish to acknowledge the financial support of KAIMRC Grant No. RC08/114, KACST Grant No. ARP-29-186, NHMRC Grant No. 509178, the RWH Foundation, Cecilia Kilkeary Foundation, Eirene Lucas Foundation, Harold & Cora Brennen Benevolent Trust (Equity Trustees), Jack Brockhoff Foundation, J & R McGauran Charitable Trust, Diana Brown Trust (Perpetual Trustees), Helen Macpherson Smith Trust, Thomas R & Rosalinda B Ditchfield Medical Research Endowment Fund and the Wenkart Foundation. There are no conflicts of interest with respect to the authors of this work.